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| Comparison of Sonographic and Histopathologic Findings
of Papillary Thyroid Carcinoma According to Galectin-3
immuno-staining in Fine-needle Aspiration Cytology
Specimens |
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| Jeong-Ah Kim, MD Eun Ju Son, MD |
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| Department of Radiology, Gangnam Severance Hospital, Yonsei University College of
Medicine |
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| Purpose: The purpose of this study is to compare the sonographic (US) and
histopathologic findings of papillary thyroid carcinoma (PTC) according to Galectin-3
(G3) immuno-staining positivity from fine needle aspiration (FNA) specimens.
Materials and Methods: US-FNA and G3 immuno-staining were performed in 343
patients. Among them, 60 patients diagnosed with PTC by surgery were included in
this study. Retrospective analysis of the clinical and US findings of PTCs (size, orientation,
margin, composition, echogenicity, vascularity, and parenchymal echogenicity)
was performed and postsurgical pathologic findings (extrathyroidal extension (ETE),
multifocality, and lymph node metastasis) were analyzed. We analyzed the correlation
of US and pathologic findings according to G3 positivity from FNA specimens.
Results: Twenty six patients (43%) were G3 negative and 34 patients (57%) were
G3 positive. No significant differences in US findings and pathologic findings of size,
multifocality, and ETE were observed between G3 positive and negative groups (p>
0.05). However, the G3 positive group had a significantly higher rate of lymph node
metastasis than the G3 negative group (p=0.008).
Conclusions: US findings did not differ between G3 positive and negative PTCs
from FNAB specimens, however, the G3 positive group had more frequent lymph
node metastasis. |
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| Keyword : Ultrasound; Galectin-3; Papillary thyroid carcinoma |
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pdf파일 : 128-131김정아.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2013 ; 32 (2) : p.128-131
