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| Comparison of Diagnostic Performance of US
Elastography and Conventional B-mode US in
Differentiation of Breast Lesions |
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| Ji Young Kang, MD1 Jin Hwa Lee, MD1, Eun-Kyung Kim, MD2,
Suyoung Shin, MD3, Byoung-gwon Kim, MD4, Jin-Han Cho, MD1,
Dong-Ho Ha, MD1, Byeong-Ho Park, MD1, Sunseob Choi, MD1 |
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| 1Department of Radiology, Dong-A University College of Medicine, Busan, Korea
2Department of Radiology, Yonsei University College of Medicine, Seoul, Korea
3Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of
Medicine, Seoul, Korea
4Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea |
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| Purpose: The purpose of this study was to compare the diagnostic performance of
ultrasound (US) elastography and conventional B-mode US for discrimination
between benign and malignant breast lesions.
Materials and Methods: During a 13-month period, 277 women with 335 sonographically
visible breast lesions who were scheduled to undergo biopsy were examined
with US elastography. Elastographic findings were classified as benign or malignant
based on the area ratio, with 1.00 as the threshold. Findings on conventional Bmode
US were classified according to the BI-RADS category, as follows: lesions of BIRADS
categories 2 and 3 were considered benign, while those in categories 4 and 5
were considered malignant. Statistical analysis included sensitivity, specificity, positive
predictive value (PPV), negative predictive value (NPV), accuracy, and ROC curve
analysis for comparison of the diagnostic performance of US elastography and conventional
B-mode US.
Results: Of the 335 breast lesions, 85 (25.4%) showed malignancy on pathology.
Findings on B-mode US showed malignancy in 264 (78.8%) and elastographic findings
showed malignancy in 102 (30.4%). The sensitivity, specificity, PPV, NPV, and
accuracy of B-mode US and elastography were 98.8%, 28.0%, 31.8%, 98.6%, and
79.4% and 69.4%, 81.2%, 57.8%, 88.8%, and 79.4%, respectively. Elastography
showed significantly higher specificity and PPV and lower sensitivity and NPV, compared
with B-mode US (p < 0.001). The area under the ROC curve (AUC value) was
0.761 for elastography, and 0.634 for B-mode US (p < 0.001).
Conclusions: US elastography can improve specificity and PPV of B-mode US,
but with significant sacrifice of sensitivity and NPV. Therefore, US elastography may
complement B-mode US for differentiation of breast masses. |
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| Keyword : Elastography; Breast US; Breast mass |
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pdf파일 : 239-245강지영.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2012 ; 31 (4) : p.239-245
