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| Ultrasonography-guided Fine-needle Aspiration for Solid
Thyroid Nodules Less than 5 mm in the Largest
Diameter: Comparison in Diagnostic Adequacy and
Accuracy According to Nodule Size |
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| Jang Hee Lee, MD1 Dong Wook Kim, MD1, Seung Hun Baek2 |
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| 1Department of Radiology, Busan Paik Hospital, Inje University College of Medicine
2Clinical Research Center, Busan Paik Hospital, Inje University College of Medicine |
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| Purpose: This study assessed the adequacy and accuracy of ultrasonography
(US)-guided fine-needle aspiration (US-FNA) of solid thyroid nodules, less than 5 mm
in maximum diameter.
Materials and Methods: From January to December 2009, US-FNA was per-
formed for small solid thyroid nodules in 201 patients. Each thyroid nodule was classi-
fied into group A and B according to the largest diameter (1 mm ≤ group A < 3 mm
and 3 mm ≤ group B < 5 mm). The adequacy and accuracy of US-FNA in two
groups were compared using the histopathological results as a reference standard.
Results: Of the 227 thyroid nodules in 201 patients, the inadequacy of US-FNA in
group A and B was 24.3% (18/74) and 13.1% (20/153), respectively, showing a statis-
tically significant difference between the two groups (p = 0.0333, chi-square test).
Eighty nodules were removed surgically in 72 patients, from which papillary thyroid
carcinoma (n = 52), follicular thyroid carcinoma (n = 1), nodular hyperplasia (n = 26),
and pseudonodule related to thyroiditis (n = 1) were confirmed. Based on the
histopathological results of the 80 surgical nodules, the sensitivity, specificity, positive
predictive value, negative predictive value and accuracy of US-FNA in group A and B
were 55.0% and 79.4%, 81.8% and 100%, 84.6% and 100%, 50% and 68.2%, and
64.5% and 85.7%, respectively.
Conclusion: The adequacy and accuracy of US-FNA for solid thyroid nodules, ≥ 3
mm in the largest diameter, were higher than those of US-FNA for very small nodules,
< 3 mm in the largest diameter. |
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| Keyword : Thyroid; Thyroid nodule; Biopsy, Fine-needle; Ultrasonography; Malignancy |
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pdf파일 : 017-21이장희.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2012 ; 31 (1) : p.17-21
