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| Analysis of the BRAFV600E Mutation in Thyroid Nodules:
the Preoperative Diagnostic Role of Fine-needle
Aspiration Biopsy for Patients with Papillary Thyroid
Cancer and Its Impact on Patient Care |
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| Ji Yeon Yang, MD1 Hyun Sook Hong, MD1,Eun Hye Lee, MD1,Chul-Hee Kim, MD2, Jeong Ja Kwak, MD3, Seung Won Lee, MD4,Jae Wook Kim, MD4 |
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| Department of Radiology, Division of Endocrinology and Metabolism, Departments of 2Internal
Medicine, 3Pathology, 4Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang
University Bucheon Hospital |
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| Purpose: We wanted to evaluate the frequency of BRAFV600E mutations on the preoperative
fine-needle aspiration biopsies (FNAB) of thyroid nodules and the effect of
this on the accuracy of diagnosing papillary thyroid cancer (PTC). We also wanted to
evaluate the influence of BRAFV600E analysis on patient care.
Materials and Methods: The results of cytology and BRAFV600E mutation analysis of
190 thyroid nodules were retrospectively reviewed. The results of the cytology and
BRAFV600E analysis were compared with the histopathological diagnosis for the surgically
confirmed cases, and we calculated the sensitivity, specificity, positive predictive
value (PPV), negative predictive value (NPV) and the diagnostic accuracy of FNAB
and combining the modalities of FNAB and BRAFV600E mutation. The frequency of
BRAFV600E mutation according to age and the influence of BRAFV600E analysis on patient
care were studied. The nodule size was compared between the malignant and other
categories of BRAFV600E positive nodules.
Results: Seventy four percent of the PTC were BRAFV600E positive. BRAFV600E analysis
increased the sensitivity, NPP and diagnostic accuracy of FNAB. Fifty percent of
the BRAFV600E positive nodules with other than malignant cytology received surgery
and these were confirmed to be PTC. The frequency of BRAFV600E mutation increased
with age, which was statistically significant. There was a statistically significant difference
in the nodule size between the cytologically malignant nodules and the other
nodules.
Conclusion: BRAFV600E analysis increased the diagnostic accuracy of FNAB and it
should be considered as being complementary to cytological analysis. The frequency
of the BRAFV600E mutation increased with age. The size of the malignant nodules was
larger than that of the benign nodules. |
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| Keyword : BRAFV600E mutation; Thyroid gland; Ultrasonography; Fine needle aspiration |
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pdf파일 : 103-112양지연.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2011 ; 30 (2) : p.103-112
