|
| Role of BRAFV600E Mutation Analysis for Thyroid Nodules Classified as Indeterminate on Ultrasonography |
|
| Sang Yu Nam, MD, Jung Hee Shin, MD, Boo-Kyung Han, MD, Eun Young Ko, MD, Seok Seon Kang, MD, Soo Yeon Hahn, MD, Ji-Young Hwang, MD, Mee Young Nam, MD, Jong-Won Kim, MD2, Jae Hoon Chung, MD3 |
|
| 1Department of Radiology and Center for Imaging Science, Samsung Medical Center,Sungkyunkwan University School of Medicine, Seoul, Korea 2Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
|
| Purpose: We aimed to evaluate a possible role for BRAFV600E mutation analysis of aspiration specimens in the work up of thyroid nodules classified as indeterminate on US.
Materials and Methods: A total of 122 nodules from 122 patients were prospectively classified as indeterminate nodules based on US findings. US-guided fine needle aspiration (FNA) was done for all 122 nodules. The presence of a BRAFV600E mutation
in FNA specimens was determined by allele-specific PCR.
Results: US-indeterminate nodules were confirmed as malignant in 20.5% (25/122) of cases and benign in 76.2% (93/122) after FNA or surgery. A few (3.3% (4/122), remained indeterminate. A BRAFV600E mutation was identified in 14.8% (18/122) of USindeterminate nodules. Of those 18 nodules, three were benign and 13 were malignant after the initial FNA. One (0.8%, 1/122) with an initially benign cytology and a BRAFV600E mutation was confirmed to be malignant after surgery. The remaining two
benign nodules with a mutation were not followed-up. All 9 initial FNA-nondiagnostic nodules were mutation negative but 2 (11.8%) of 17 indeterminate nodules on initial FNAs were mutation positive.
Conclusion: BRAFV600E mutation analysis prevents false negative cytology for only 0.8% of cases and reduces ambiguous diagnoses for 1.6% of all US-indeterminate thyroid nodules. Therefore, adding BRAFV600E mutation analysis to FNA for US-indeterminate
nodules is of limited usefulness. |
|
| Keyword : Thyroid neoplasms; Ultrasonography; Fine needle aspiration;BRAF mutation; Thyroid cancer |
|
pdf파일 : 045-51남상유, 신정희.pdf 
|
|
> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2010 ; 29 (1) : p.45-51
