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| Analysis of the Malignancy Rate for Thyroid Nodules based on the Use of a Fine Needle Aspiration Biopsy and Ultrasonography |
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| Ju Wan Choi, M.D. Ji Won Park, M.D., Han Young Jeong, M.D.,Hye Jung Kim, M.D., Gab Chul Kim, M.D., Yong Sun Kim, M.D.,Ji Young Park, M.D.*, Hui Joong Lee, M.D. |
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| Department of Radiology, Kyungpook National University Hospital,*Department of Pathology, Kyungpook National University Hospital |
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| PURPOSE : This study was designed to analyze the malignancy rate for thyroid nodules determined after a fine needle
aspiration biopsy (FNAB) and ultrasonography (US) and to propose follow-up FNAB indications.
MATERIALS and METHODS : A total of 287 patients (265 female, 22 male) who underwent repeated US-guided FNABs were included in the cohort study. The results of the FNABs were classified as inadequate, benign, indeterminate,suspicious for a malignancy and a malignancy. The US findings were assigned five grades according to the possibility of a malignancy present. The frequency of a malignant nodule was evaluated by the use of the
Kaplan-Meier method and Cox proportional risk model.
RESULTS : The malignancy rates of inadequate, benign, and indeterminate nodules were 12.8%, 8.2% and 37.5%, respectively, for the FNAB findings. The rates of grades 3, 4 and 5 were 38.6%, 50.0% and 53.8%, respectively,for the US findings. Inadequate and indeterminate nodules as determined by an FNAB and grades 3, 4 and 5 assigned after US showed a higher malignancy rate than other nodules and would be regarded as high risk lesions.The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 93.3%,38.4%, 22.0%, 96.9% and 47.0%, respectively, if the nodule was considered a high-risk lesion, based on the
FNAB or US findings.
CONCLUSION : Thyroid nodules should be evaluated based on an FNAB and US findings. If a thyroid nodule is classified
as a high-risk lesion, a follow-up study is needed due to the high malignancy rate. |
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| Keyword : Thyroid nodule; Fine needle aspiration biopsy; Thyroid US |
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pdf파일 : 213-219최주완.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2008 ; 27 (4) : p.213-219
