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| Effectiveness of Ultrasonography in Differential Diagnosis of Nonpalpable Breast Nodules |
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| Young Kyung Lee, M.D. Sun Mi Kim, M.D., Jeong Mi Park, M.D. |
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| Department of Radiology, Asan Medical Center, University of Ulsan, College of Medicine |
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| PURPOSE : We evaluated the effectiveness of ultrasonography (US) in differential diagnosis of nonpalpable breast
nodules.
MATERIALS and METHODS : From January 2000 to June 2001, US-guided fine needle aspiration biopsy (FNAB) was
performed in 610 nonpalpable breast nodules from 511 patients. Pre-biopsy US diagnosis was divided into 311
benign and 299 non-benign (malignant and indeterminate) categories. Diagnostic accuracy of Pre-biopsy US
was calculated according to the size of lesion. All lesions were pathologically diagnosed by US-guided FNAB
while excisional biopsy was performed in 12 cases.
RESULTS : Overall, 136/143 FNAB-proven malignant nodules (95.1%) and 304/467 FNAB-proven benign nodules
(65.1%) were correctly predicted by US. The overall diagnostic accuracy was 72.1% while the sensitivity, specificity,
positive predictive value, negative predictive value and accuracy were highest for the nodules sized between
1-2cm in the longest diameter (98.1%, 70.1%, 47.7%, 99.2% and 76.2%, respectively). The number of
false negative malignancies were seven (4.9%); four of them, smaller than 1cm. False negative malignancies
showed ovoid or round in shape, well defined margin and homogeneous echogenecity. Meanwhile, frequent US
findings of indeterminate nodules included ill-defined margin, microlobulated border, angular margin and
marked hypoechogenecity; however, 86% of them were proved to be benign.
CONCLUSION : Ultrasonography is an effective diagnostic method in differential diagnosis of nonpalpable breast
nodules, especially for 1-2 cm sized nodules. However, US characteristics suggestive of malignacy were also
frequently seen in benign lesions. |
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| Keyword : Breast, Breast neoplasms, diagnosis, Breast neoplasms, US |
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pdf파일 : 59-65이영경.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2003 ; 22 (2) : p.59-65
