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| Correlation of Contrast Enhanced Power Doppler Sonographic |
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| Boo-Kyung Han, M.D. Young-Hyeh Ko, M.D.*,Yeon Hyeon Choe, M.D., Kyoung-Sik Cho, M.D**. |
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| Departments of Radiology and Pathology*, Samsung Medical Center, Sungkyunkwan University School of Medicin **Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center |
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| PURPOSE : To compare the pre-and postenhanced power Doppler sonographic (PDS) findings in malignant and benign
breast masses and to correlate between power Doppler area (PDA) and histologic microvessel density
(MVD).
MATERIALS and METHODS : Forty-seven women with breast masses (27 malignant and 20 benign) underwent PDS before
and after an injection of microbubble contrast agent (LevovistⓇ) for five minutes. Using computer-assisted
quantification, intratumoral % PDA was calculated. Microvessel density was counted on the digitized image of
slides stained with anti CD 31 monoclonal antibody.
The statistical analysis was performed using t-test to determine the difference of % PDA between malignant and
benign masses and between <2 cm and ≥2 cm in size. The correlation between % PDA and MVD was investigated
by Pearson’s correlation test.
RESULTS : % PDA on pre-enhancement PDS did not show a statistically significant difference between malignant
and benign breast masses (4.3% and 3.9%, p>0.3). On a 30-second post-enhancement PDS, the difference between
malignant and benign masses in % PDA showed a statistical significance (28.3% and 11.0%, p<0.05),
but the difference in size of masses was not statistically significant (p>0.05). MVD was well correlated with %
PDA on post-enhancement PDS (r=0.69), and a stronger correlation was seen in malignant masses (r=0.71).
CONCLUSION : Contrast-enhanced PDS is superior in demonstrating the difference of vascularity between malignant
and benign breast masses. % PDA after contrast-enhancement exhibited a statistically significant correlation
with histologic MVD. |
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| Keyword : Breast Neoplasms, US Ultrasound (US), Doppler studies Angiogenesis |
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pdf파일 : 55-64한부경.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2002 ; 21 (1) : p.55-64
