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| Contrast-enhanced Harmonic Power Doppler Ultrasonography:Improved Depiction of Vascularity and Characterization of Flow Pattern in Hepatocellular Carcinoma |
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| Hyung Chul Baek Kwon-Ha Yoon, M.D.,Chang Guhn Kim, M.D., Ki Han Park, M.D., Jong Jin Won, M.D. |
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| Department of Radiology, Wonkwang University School of Medicine |
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| PURPOSE : To evaluate the value of contrast-enhanced harmonic power Doppler ultrasonography (PDUS) in depiction
and characterization of tumoral vascularity in hepatocellular carcinoma (HCC).
MATERIALS and METHODS : Thirty-three patients with HCC were prospectively evaluated with harmonic PDUS before
and after injection of the contrast agent SH U 508A (2.5g, 300 mg/ml). Unenhanced and serial dynamic scans
at 15, 30, 45, 60, 90, 120, 150, 180, 240, 300 seconds after injection of contrast agents were obtained using
a tissue harmonic technique with power Doppler imaging. The tumoral vascularity was expressed as percentage
of power Doppler area, which was measured quantitatively by a computerized program (Ultrasonic Imaging
Tool; Soongsil University, Seoul, Korea). The grade (0, no signal; 1, less than 5%; 2, 5-25%; 3, more than 25%)
and flow pattern (intratumoral, detour, basket, and mixed) of tumoral vascularity were analyzed. Peak time of
contrast-enhancement was measured on each tumor.
RESULTS : After injection of contrast agent, tumoral flow signals increased in all lesions (100%). At unenhanced harmonic
PDUS, flow signals were detected in 17 HCCs (52%); 15 tumors (46%) demonstrated grade 1 vascularity;
and two (6%), grade 2. At contrast-enhanced harmonic PDUS, all tumors were detected vascularity; five
(15%) were grade 1; eight (24%), grade 2; and 20 (61%), grade 3. Flow patterns were demonstated as follows at
unenhanced harmonic PDUS; intratumoral pattern in 13 tumors (76%), detour in 2 (12%), and basket in 2
(12%). After injection of contrast agent, intratumoral pattern in 7 tumors (21%), detour 0 (0%), basket in 3 (9%)
and mixed in 23 (70%) were demonstrated. Peak time of enhancement after injection of contrast agent was 30-
90 seconds in majority of the patients.
CONCLUSION : Contrast-enhanced harmonic PDUS would be valuable in depiction of vascularity and characterization
of flow pattern in HCC. |
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| Keyword : Liver neoplasms,Ultrasound (US), contrast media,Ultrasound (US), power Doppler studies |
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pdf파일 : 233백형철.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2000 ; 19 (4) : p.233-238
