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| Contrast-Enhanced Color Doppler US in Breast Cancer : Tumoral Vascularity Correlated with Angiogenesis |
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| Eun A Kim Kwon-Ha Yoon, Ki Jung Yun, Kwang Man Lee, Ki Han Park, Seon-Kwan Juhng, Jong Jin Won |
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| Department of Radiology, Wonkwang University School of Medicine |
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| PURPOSE : To evaluate the effects of contrast-enhanced color Doppler ultrasonography (CDUS) on the depiction of
vascularity and flow pattern in breast cancer and to determine the relationship between tumoral vascularity and
angiogenesis.
MATERIALS and METHODS : Twenty-one patients with breast cancer were prospectively evaluated with CDUS before
and after injection of the contrast agent (SH U 508A, 2.5g, 300mg/ml). The tumoral vascularity was expressed
as percentage of color Doppler area, which was measured quantitatively by a computerized program (Ultrasonic
Imaging Tool; Soongsil University, Seoul, Korea). The flow pattern (four-patterns; spotty, linear, branching,
marginal) of the vascularity was analyzed. After surgery, tumor angiogenesis was assessed by microvessel density.
The relationship between the vascularity on CDUS and microvessel density was statistically analyzed.
RESULTS : At unenhanced CDUS, tumoral flow signals were detected in 12 lesions (48%); at contrast-enhanced
CDUS, 18 lesions (86%). All These 18 lesions showed increased signals, compared with those at unenhanced
CDUS. The percentage color Doppler area was 1.86±0.48% at unenhanced CDUS and 5.23±1.18% at contrast-
enhanced CDUS. The flow patterns before contrast injection were spotty pattern in 11 tumors and linear
pattern in one; after contrast injection, spotty in 8, linear in 4, branching in 5, and marginal in one. The tumoral
vascularity at contrast-enhanced CDUS showed no significant correlation with microvessel density.
CONCLUSION : Contrast-enhanced CDUS seems to be a valuable tool in the depiction of vascularity and characterization
of flow pattern in breast cancer. However, tumoral vascularity on CDUS may not reflect tumoral angiogenesis. |
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| Keyword : Breast, US, Breast neoplasms, Breast neoplasms, US |
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pdf파일 : 311김은아.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2000 ; 19 (4) : p.311-318
