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| VX2 Carcinoma in Rabbit Liver: Different Radiologic Features According to Innoculation Methods |
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| Joon Woo Lee M.D., Jin Wook Chung, M.D., Guk Myeong Choi, M.D.,Chong Jai Kim, M.D.,Kyoung Ho Lee, M.D., Seung Hyup Kim, M.D., Jae Hyung Park, M.D. |
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| Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine,*Halla Hospital, **Department of Pathology, Seoul National University College of Medicine |
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| PURPOSE : To investigate radiologic features about hepatic VX2 carcinoma induced by two methods, direct intra-parenchymal
innoculation vs transportal approach, focus on enhancement pattern and comparison of each imag-ing
modalities and innoculation methods.
MATERIALS and METHODS : VX2 carcinomas were induced in 11 rabbit livers by direct inoculation (n = 7) or infusion
into mesenteric vein (n = 4). After two weeks, spiral CT, digital subtraction angiography (DSA), intravenous
contrast-enhanced power Doppler sonography, intraarterial CO 2 sonography were done. The enhancement pat-terns
were assessed independently and correlated with histopathologic features.
RESULTS : With direct intraparenchymal innoculation, localized hepatic VX2 tumors were developed. Considering
all imaging modalities, six of 7 tumors appeared peripheral hypervascularity, one hypovascularity. On patholog-ic
and radiologic correlations, the enhancing portions of 4 tumors corresponded to viable tumor and pseudo-cap-sule
portion, the other enhancing portions of 2 tumors corresponded to sinusoidal vascular spaces. With the
transportal approaches, diffuse hepatic tumors were developed. Spiral CT and DSA revealed these tumors as
marked peripheral hypervascular tumors with multiple A-P shunts. On pathologic findings, multiple thin walled
sinusoidal spaces were seen at periphery of nodule. Spiral CT was superior to the other modalities in evaluation
of enhancement characteristics.
CONCLUSION : VX2 carcinomas in rabbit livers showed different radiologic and histopathologic features according
to the innoculation methods. |
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| Keyword : Liver neoplasms, Liver neoplasms, CT, Liver neoplasms, US, Liver neoplasms, angiography |
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pdf파일 : 161이준우2.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 2000 ; 19 (3) : p.161-170
