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| Doppler Wave f o rm of Hepatic Vein in Patients with ChronicHepatitis B : Correlation with Histologic Grade and Stage |
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| Kyeong Tae Eom, M.D. Sook Namkung, M.D.,Sang Hoon Bae, M.D., Young Hee Choi, M.D. |
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| Department of Radiology, College of Medicine, Hallym University, Department of Pathology, College of Medicine, Hallym University |
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| PURPOSE : To evaluate the relationship between the waveform of the right hepatic vein and the histological grade
and stage in patients with chronic hepatitis B.
MATERIALS and METHODS : Eighty-seven patients with chronic hepatitis B were examined prospectively by one sono-g
rapher. In each patient, Doppler waveform of the right hepatic vein was obtained. Doppler waveform was clas-sified
into 3 types, type 0: normal triphasic pattern, type 1: reduced amplitude of phasic oscillation and no re-verse
flow phase, and type2: completely flat flow pattern. In the same session, an ultrasound guided liver biopsy
was performed and submitted to one pathologist for grading and staging. Duplex doppler ultrasonography of the
right hepatic vein was also performed in 12 control subjects with no evidence of liver or heart disease. The
doppler waveform was compared with the histologic severity and a statistical analysis was performed.
RESULTS : In the control group, all cases had type 0 waveform. In the hepatitis group, there were type 0 waveform in
61 cases(70.1%), type 1 waveform in 22 cases(25.3%) and type 2 waveform in 4 cases(4.6%). The frequency of
abnormal waveforms is significantly higher in patients with grade 3-4 and stage 3-4 than grade and stage 1-
2(p<0.005). In the hepatitis group, the venous pulsatility index(VPI) was 0.17-0.69(mean 0.41), and decreased
in the highest and mean values when increasing the histologic scores. However, it was not significant statistical-l
y(p>0.05).
CONCLUSION : The frequency of abnormal waveform was correlated with the histologic severity in patients with
chronic hepatitis B. The highest and mean values of the VPI were also correlated. However 70.1% of the pa-tients
with chronic hepatitis B showed normal waveform. So doppler ultrasonogram of the hepatic vein may be
useful for the diagnosis and the differential diagnosis from cirrhosis in patients with chronic hepatitis B by com-bination
of doppler waveform and venous pulsatility index. |
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| Keyword : Ultrasound (US), Doppler studies, Hepatitis, Hepatic veins, US |
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pdf파일 : 275엄경태.pdf 
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> Journal > Journal Search 
Journal of Korean Society of Ultrasound in Medicine 1999 ; 18 (4) : p.275-281
